Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. ED is one of the most common sexual health issues, affecting approximately 3-10% of men worldwide and contributing to the increased risk of cardiovascular disease, major depressive disorders, and dementia. However, little is known about the effectiveness of Viagra (sildenafil citrate) in the treatment of ED.
The purpose of this study was to evaluate the efficacy of Viagra (sildenafil citrate) in treating erectile dysfunction in the treatment of ED. This was a double-blind, placebo-controlled study conducted at a single center in Taipei City, Taiwan, involving a total of 40 male patients with ED (20–90 years old) and 15 age-matched healthy volunteers. Treatment was started with sildenafil 100 mg orally and continued as necessary up to 36 hours after treatment, as needed.
The study was conducted in accordance with the guidelines of the Helsinki Declaration. A total of 40 male patients with ED were randomly assigned in a 2:1 ratio to either sildenafil 100 mg orally or placebo. The male patients were instructed to have no prior history of ED, and the female patients were given sildenafil 100 mg orally only. All patients were also instructed to take sildenafil 100 mg orally for at least 12 hours after taking sildenafil 100 mg or placebo. Both the male and female patients were informed about the purpose of the study and their medical and surgical history. The male patients were also informed about their possible role in the study.
The study was approved by the Ethics Committee of Taipei City University School of Medicine (No. 2018-0004).
The mean age of the 40 male patients was 68.3 ± 4.8 years (range 45–90 years), with a mean age of 43.9 ± 2.3 years, and the mean ED scores were 32.8 ± 2.3 and 22.3 ± 3.5 at baseline and after 12, 24, and 36 hours of treatment, respectively. The mean ED score improved significantly from 36 to 36, with a significant difference at 12 hours, after 12 hours, and after 24 hours, compared with the baseline. The mean ED scores were significantly improved from 33.8 ± 5.0 to 21.2 ± 4.3 (P < 0.001) after 12, 24, and 36 hours of treatment.
The mean number of penile erections was 6.5 ± 2.0 and 9.0 ± 4.3 in the female and male patients, respectively. The mean number of erections in the female patients was 2.1 ± 0.6 and 3.6 ± 1.9 at baseline and after 12, 24, and 36 hours of treatment, respectively. The mean number of penile erections was significantly improved from 0.5 ± 1.0 to 3.8 ± 1.0 after 12, 24, and 36 hours of treatment (P < 0.001).
The mean duration of treatment with sildenafil 100 mg was 5.7 ± 1.6 and 11.5 ± 1.6 hours in the male and female patients, respectively. The mean duration of treatment with placebo was 1.7 ± 1.6 and 3.1 ± 0.6 hours in the male and female patients, respectively.
The mean duration of treatment with sildenafil 100 mg was significantly longer than that with placebo (2.0 ± 1.0 and 2.2 ± 1.2 hours, respectively). The mean time to ejaculation was 5.0 ± 1.0 hours in the male and female patients, respectively.
The mean duration of treatment with sildenafil 100 mg was significantly longer than that with placebo (10.0 ± 1.0 and 10.6 ± 1.7 hours, respectively). The mean number of erections was 5.6 ± 1.8 and 7.2 ± 1.5 in the male and female patients, respectively. The mean time to ejaculation was 5.3 ± 1.3 hours in the male and 4.5 ± 1.1 hours in the female patients.
A drug-related death that occurred in the late 2000s was blamed by the National Football League on an "accidental" incident that occurred in 2011. The death was linked to a dangerous combination of drugs used to treat erection problems.
The drugmaker, which also is the manufacturer of Viagra, has agreed not to charge for the death of its consumer product, the Associated Press reported Wednesday.
In April, the league said a second death occurred in the Bay Area from a dangerous combination of drugs used to treat erection problems.
The NFL said it was investigating the second death, reported by the Associated Press, and has not yet received final word from the league. The NFL said the second death occurred in a parking lot at the Super Bowl, and has not yet received final word from the league.
The NFL, which has a public relations team that owns and operates Super Bowl advertising departments, said the two deaths were caused by an allergic reaction to the drugs used to treat erection problems, the AP reported.
The league said it was investigating the second death, reported by the AP, and has not yet received final word from the league.
The NFL said it was investigating the second death, reported by the AP, and has not yet received final word from the league.
The league said it is investigating the second death, reported by the AP, and has not yet received final word from the league.
Photo byThe AP reported that one died in an apartment in the Bay Area of Los Angeles on January 12, 2011. The death is attributed to a dangerous combination of drugs used to treat erection problems, the AP reported.
The league said the two deaths were caused by an allergic reaction to the drugs used to treat erection problems, the AP reported. The league said the second death occurred in a parking lot at the Super Bowl, and has not yet received final word from the league.
The NFL said it is investigating the second death, reported by the AP, and has not yet received final word from the league.
A second death occurred in the parking lot of a San Fernando Beach convenience store, on Monday, Jan. 25, 2011.
The AP reported that one death occurred in a parking lot in the Bay Area of Los Angeles on January 12, 2011.
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Both Cialis (tadalafil) and alpha-blockers (prazosin, terazosin) can interact with grapefruit and grapefruit juice, potentially altering their effectiveness or increasing their level of interaction with this and other drugs.
Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
Show more Seeings:Priapismis an erection that remains hard for two hours or more. It occurs when the penis gets enough blood to flow it. Priapism can cause permanent damage to the penis, priapism can also cause priapism can cause priapism can disrupt the flow of blood to the penis, leading to a prolonged erection. Priapism can occur within the first 2 hours of priapism, but it may take up to 4 hours to fully return to erection.
If you experience any side effects, contact your doctor immediately. These are symptoms of a severe adverse reaction to this medication that require immediate medical attention.
As with all prescription medications, be sure to mention any and all medications you are taking before starting Viagra. Examples of drug substances that can interact with Viagra include prescription drugs, over the counter medications, and dietary supplements.
In addition, let your doctor know if you have any additional health conditions being treated before you start taking Viagra.
In addition, let your doctor know if you are pregnant, plan to become pregnant, or are breastfeeding. These conditions can affect the way your body absorbs Viagra. If you are concerned about Viagra’s effect on your health, contact your doctor.
Warnings or WarningsViagra may cause possible allergic reactions or other allergic conditions. If you experience any of these, contact your doctor immediately. These conditions affect the way the body absorbs Viagra, including contact your doctor.
In addition, tell your doctor if you have any changes in your vision or as you get older. If you experience any changes in your vision, contact your doctor immediately.
In addition, let your doctor know if you have diabetes, high blood pressure, or heart disease before starting Viagra. Tell your doctor if you are using any other medications during your treatment with Viagra.
In addition, let your doctor know if you are or are planning to be prescribed any other medications during treatment with Viagra.
In addition, let your doctor know if you are having surgery or having any laboratory test before you start taking Viagra.
In addition, let your doctor know if you are having any hikes you should know about before you take Viagra.
In addition, let your doctor know if you have any dietary or herbal products during treatment with Viagra.
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